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Updated: Jun 3, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

KSRのラフ誘発性アロステリック変異は,MEKのリン酸化を刺激する

Damian F Brennan1, Arvin C Dar, Nicholas T Hertz

  • 1Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

Nature
|March 29, 2011
PubMed
まとめ

Ras (KSR) のキナーゼ抑制剤は,Raf-MEK-ERKシグナル伝達を支えている. 構造と生化学の研究では,KSR2-BRAFヘテロダイマーがMEKリン酸化を活性化し,がん治療の洞察を提供することを明らかにしています.

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Bioluminescence Resonance Energy Transfer (BRET)-Based Assay for Measuring Interactions of CRAF with 14-3-3 Proteins in Live Cells06:44

Bioluminescence Resonance Energy Transfer (BRET)-Based Assay for Measuring Interactions of CRAF with 14-3-3 Proteins in Live Cells

Published on: March 1, 2024

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

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