T2*では,磁気共鳴と心臓の鉄を検査する
John-Paul Carpenter1, Taigang He, Paul Kirk
1Royal Brompton and Harefield NHS Trust, London, SW3 6NP, UK.
Circulation
|March 30, 2011
まとめ
心血管磁気共振 (CMR) を用いた心臓の鉄の正確な測定は,シデロティック心筋症の管理に不可欠です. この研究は,ヒトにおけるCMR R2*から心筋臓の鉄濃度への校正を提供し,現在の臨床慣行を検証しています.
科学分野:
- 心臓病学 心臓病学
- メディカルイマージング (医学イメージング)
- バイオフィジックス 生物物理学
背景:
- 筋動脈の鉄の測定は,シデロティック心筋病変症の管理に不可欠です.
- 心血管磁気共振 (CMR) R2* (T2*) は心臓の鉄を評価しますが,ヒトの校正データは限られています.
研究 の 目的:
- 肌動脈鉄濃度に対するCMR R2*のヒトの校正方程式を確立するために.
- 人間の心臓内の鉄の分布を調査するために.
主な方法:
- 輸血依存の患者から12人の人間の心臓を研究した.
- 誘導結合プラズマ原子放射光譜を用いて,心筋鉄濃度を測定した.
- CMR R2*値と相関する心筋鉄濃度.
主要な成果:
- エピカルディアの鉄濃度が内心臓の濃度より高かった.
- カリブレーション方程式を開発しました: [Fe]=45.0×(T2*) −1·22.
- 中心室隔膜の鉄濃度とR2*は,世界平均の心筋鉄を代表しています.
結論:
- CMR R2* から心筋鉄濃度までのヒトの校正を提供します.
- 過剰な心臓の鉄濃度は,心不全や死亡と関連しています.
- ミッドセプタム経由で心鉄のCMRモニタリングをin vivoで検証する.
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