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Updated: Jun 3, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
08:49

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

構造的に洗練された八面体金属複合体は,高度に選択的なタンパク質キナーゼ阻害剤として使用されます

Li Feng1, Yann Geisselbrecht, Sebastian Blanck

  • 1Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, 35043 Marburg, Germany.

Journal of the American Chemical Society
|March 31, 2011
PubMed
まとめ

研究者は,高度に選択的なタンパク質キナーゼ阻害のための新しい金属含有化合物を開発しました. これらの化合物は,ルテニウム (II) またはイリジウム (III) センターの周りのユニークな幾何学を用いて,特定のキナーゼを標的とし,従来の有機分子の限界を克服します.

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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors10:33

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Protein Kinases and Phosphatases02:54

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