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Updated: May 4, 2026

Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal
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Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal

Published on: May 30, 2012

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ネズミの胚性幹細胞における転写調節におけるTet1の二重機能

Hao Wu1, Ana C D'Alessio, Shinsuke Ito

  • 1Department of Molecular & Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, California 90095, USA.

Nature
|April 1, 2011
PubMed
まとめ

10-11転位1 (Tet1) タンパク質は,マウスの胚性幹細胞におけるDNAメチル化を調節する. Tet1は多能性因子の発現を促進し,PRC2.2を勧誘することによって発育遺伝子を抑制する.

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