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Updated: Jun 3, 2026

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
07:03

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides

Published on: January 31, 2014

プロリルペプチド結合イソメリゼーションのエネルギー学への誘導効果:コラーゲン折り畳みと安定性への影響

Eric S Eberhardt1, Nicholas Panisik, Ronald T Raines

  • 1Contribution from the Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706-1569.

Journal of the American Chemical Society
|April 1, 2011
PubMed
まとめ

コラーゲン内のプロリン残基の水酸化により,安定性が向上します. プロリンの置換物は,アミド結合特性とトランス同位体濃度に影響を与え,コラーゲンの折り畳みと安定性に影響を与えます.

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関連する概念動画

Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
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Protein Folding01:22

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Protein Folding01:22

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Peptide Bonds02:43

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
Protein Organization01:13

Protein Organization

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Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.