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Updated: Jun 3, 2026

Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System
04:47

Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System

Published on: May 22, 2020

RPTPσのクラスタリングとニューロンの拡張のためのプロテオグリカン特有の分子スイッチ

Charlotte H Coles1, Yingjie Shen, Alan P Tenney

  • 1Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

Science (New York, N.Y.)
|April 2, 2011
PubMed
まとめ

ヘパランとコンドロイチン硫酸プロテオグリカン (HSPGとCSPG) は,受容体タンパク質チロシンフォスファターゼシグマ (RPTPσ) 経由で感受性ニューロン拡張に相反する効果を持っています. RPTPσはCSPGによる抑制とHSPGによる促進を媒介し,新しい規制メカニズムを明らかにします.

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