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Updated: Jun 3, 2026

DNAzyme-dependent Analysis of rRNA 2’-O-Methylation
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RNAポリメラーゼIIのC端末ドメインは,サイト固有のメチル化によって変化する

Robert J Sims1, Luis Alejandro Rojas1, David B Beck1

  • 1Howard Hughes Medical Institute (HHMI), Department of Biochemistry, New York University School of Medicine, 522 First Avenue, Smilow 211, New York, NY 10016, USA.

Science (New York, N.Y.)
|April 2, 2011
PubMed
まとめ

RNAポリメラーゼII (RNAPII) のCTDメチル化は,R1810でのCARM1により,転写開始前に行われます. このメチル化は,特定の小さなRNAの発現に不可欠であり,遺伝子調節に影響を与えます.

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Eukaryotic RNA Polymerases00:58

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RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
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