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Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
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Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...

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Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices
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Published on: March 8, 2024

DISC1に依存したスイッチは,原始細胞の増殖から,発達中の皮質の移住へと移行します.

Koko Ishizuka1, Atsushi Kamiya, Edwin C Oh

  • 1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

Nature
|April 8, 2011
PubMed
まとめ
この要約は機械生成です。

DISC1タンパク質のリン酸化は,脳内の分子スイッチとして作用します. このスイッチは,皮質形成の過程で,原始細胞の増殖とニューロン移動を制御し,精神障害の感受性に影響を与えます.

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Ex Vivo Culture of Chick Cerebellar Slices and Spatially Targeted Electroporation of Granule Cell Precursors
10:02

Ex Vivo Culture of Chick Cerebellar Slices and Spatially Targeted Electroporation of Granule Cell Precursors

Published on: December 14, 2015

関連する実験動画

Last Updated: Jun 3, 2026

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices
04:17

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Published on: March 8, 2024

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
09:25

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

Published on: June 4, 2014

Ex Vivo Culture of Chick Cerebellar Slices and Spatially Targeted Electroporation of Granule Cell Precursors
10:02

Ex Vivo Culture of Chick Cerebellar Slices and Spatially Targeted Electroporation of Granule Cell Precursors

Published on: December 14, 2015

科学分野:

  • 神経科学は神経科学である.
  • 発達生物学 発達生物学とは
  • 分子生物学は分子生物学である.

背景:

  • 皮質新生は,原始細胞の増殖とニューロン移動の正確な調節を伴う.
  • 精神障害の感受性因子であるDISC1 (統合失調症の障害1) の機能が,皮質形成における役割は完全に理解されていません.
  • 増殖と移住を切り替える正確な分子機構は,未だに曖昧である.

研究 の 目的:

  • DISC1のリン酸化が,皮質新生期における原始細胞増殖からニューロン移動への移行を調節する役割を解明する.
  • GSK3βおよびバルデット-ビドル症候群 (BBS) のタンパク質との相互作用を含むDISC1の分子相互作用を調査する.
  • DISC1の特定のリン酸化イベントが,神経発達におけるその機能にどのように影響するのかを決定する.

主な方法:

  • コルチコゲネシスを研究するためにマウスモデルを使用した.
  • セリン710 (S710) で研究されたDISC1リン酸化.
  • DISC1,GSK3β,およびBBSタンパク質の間の相互作用を,遺伝子操作と生化学的測定を用いて調べました.
  • DISC1のノックダウンと特定のDISC1変異体 (フォスフォデッドとフォスフォミミック) が細胞増殖と移動に及ぼす影響を評価した.

主要な成果:

  • 非酸化DISC1はGSK3βと相互作用し,Wnt信号伝達を調節し,原始細胞の増殖を維持する.
  • S710におけるDISC1のリン酸化は,BBSタンパク質をセンターソームに誘導し,神経細胞の移動を促進する.
  • BBS1の消失は特に移住を阻害し,DISC1の消失は拡散と移住の両方に影響を及ぼします.
  • リン酸死DISC1変異体は増殖を救出し,リン酸模倣変異体は移住を救出し,スイッチ機能を確認した.

結論:

  • DISC1は,前因子増殖とニューロン移動の両方を調節して,皮質形成において二重の役割を果たします.
  • S710におけるDISC1のリン酸化は,増殖から移住へと移行する重要な分子スイッチとして作用する.
  • DISC1およびBBSタンパク質を含むこのリン酸化依存のスイッチメカニズムは,適切な脳発達に不可欠であり,精神障害に影響を及ぼす可能性があります.