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Updated: Jun 3, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
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CD80とCD86のトランスエンドサイトーシス:CTLA-4の細胞外的機能の分子基盤

Omar S Qureshi1, Yong Zheng, Kyoko Nakamura

  • 1Medical Research Council (MRC) Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham B15 2TT, UK.

Science (New York, N.Y.)
|April 9, 2011
PubMed
まとめ

細胞毒性Tリンパ球抗原4 (CTLA-4) は,トランスエンドシトーシス経由でCD80/CD86リガンドを捕獲することによって,T細胞の反応を抑制する. この枯渇はCD28経由の共刺激を阻害し,CTLA-4を明らかにする.

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