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Updated: Jun 2, 2026

Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs
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Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs

Published on: June 12, 2018

CPEBと2つのポリア) ポリメラーゼは,miR-122の安定性とp53mRNAの翻訳を制御する

David M Burns1, Andrea D'Ambrogio, Stephanie Nottrott

  • 1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

Nature
|April 12, 2011
PubMed
まとめ

生殖線発達2 (Gld2) 欠陥の枯渇は,驚くほどp53 mRNA翻訳と細胞老化を強化する. この研究では,Gld2,miR-122,細胞質ポリアデニレーション要素結合タンパク質 (CPEB),およびGld4が衰老を制御する新しい調節経路を明らかにしました.

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