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Updated: Jun 2, 2026

11:56
Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
HSV-2感染の症状および無症状の人の間でのヘルペス・シンプレックスウイルスの性器の流出
Elizabeth Tronstein1, Christine Johnston, Meei-Li Huang
1Department of Medicine, University of Washington, Seattle, USA.
JAMA
|April 14, 2011
まとめ
症状のある性器ヘルペスシンプレックスウイルス2型 (HSV-2) の個人は,無症状の感染者よりも頻繁にウイルスを流す. しかし,生殖器の病変の存在は,症状のある症例におけるより高い脱毛率に大きく寄与します.
科学分野:
- ウイルス学 ウイルス学 ウイルス学
- 感染症 感染症は感染症です.
- エピデミオロジー エピデミオロジー
背景:
- 生殖器ヘルペスシンプレックスウイルス2型 (HSV-2) の診断は,広範な血清検査により増加しています.
- 無症状の個体におけるHSV-2の自然経歴は不明である.
研究 の 目的:
- 症状と無症状のHSV-2感染で生殖器のHSVの流出のウイルス学的および臨床的経過を比較する.
主な方法:
- 498人の免疫力のある,HSV-2陽性の個人が,生殖器のHSVの流出に関する前向きな研究に参加しました.
- 参加者は,少なくとも30日間,毎日自己採取した生殖器スワンブを採取しました.
- 生殖器スランプのHSVDNAは,リアルタイム光ポリメラーゼ連鎖反応を用いて定量化されました.
主要な成果:
- HSV-2は,症状のある個体では20.1%の日に検出され,無症状の個体では10.2%の日に検出されました (P < .001).
- サブクリニックの脱毛率は,無症状 (8.8%) の個人に比べて,症状のある (13.1%) の個人に比べて高かった (P < .001).
- 生殖器の病変は,症状のある症例では排泄日の43.0%を占め,無症状の症例では16.4%であった (P < .001).
結論:
- 症状のないHSV-2感染は,症状のある感染と比較して,より頻繁な生殖器のウイルス流出と関連しています.
- 流出率の違いは,主に生殖器の病変の存在によるもので,それは頻繁にウイルスの流出に伴います.
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