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Measuring Diaphragm Thickness and Function Using Point-of-Care Ultrasound05:51

Measuring Diaphragm Thickness and Function Using Point-of-Care Ultrasound

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Diaphragm thickness and function can be assessed in healthy individuals and critically ill patients using point-of-care ultrasound. This technique offers an accurate, reproducible, feasible, and well-tolerated method for evaluating diaphragm structure and function.
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The goal of this protocol is to enable non-dental professionals to assess oral health status for research or health-screening purposes. Aspects assessed include lips, tongue, soft and hard tissues, natural and artificial teeth, oral cleanliness, plaque, swallowing, and impact of oral health on quality of...
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The goal of the protocol is to provide an industrialized fish fermentation technique based on inoculation of Saccharomyces...
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The goal of this protocol is to measure the effect of glucose-mediated changes to mitochondrial respiration in the presence of natural compounds on intact 832/13 beta cells using high-resolution respirometry.
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A protocol to evaluate changes in DNA damage levels and DNA repair capacity that may be induced by chronic in vivo low dose irradiation in mouse spleen lymphocytes, by measuring phosphorylated histone H2AX, a marker of DNA double-strand breaks, using flow cytometry is presented.
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Keeping the microscope optics clean is important for high-quality imaging. Dust, fingerprints, excess immersion oil, or mounting medium on or in a microscope causes reduction in contrast and resolution. DIC is especially sensitive to contamination and scratches on the lens surfaces. This protocol details the procedure for keeping the microscope...
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人間の誘発性多能幹細胞を用いた統合失調症のモデル化.

Kristen J Brennand1, Anthony Simone, Jessica Jou

  • 1Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla California 92037, USA.

Nature
|April 15, 2011
PubMed
まとめ
この要約は機械生成です。

研究者は,統合失調症 (SCZD) を研究するために,患者の細胞をニューロンに再プログラムしました. 彼らは,SCZDニューロンの接続性が低下し,分子変化を特定し,この複雑な遺伝的精神疾患に関する新しい洞察を提供することを発見しました.

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Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
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科学分野:

  • 神経科学は神経科学である.
  • 遺伝学 遺伝学とは
  • 幹細胞生物学 幹細胞生物学

背景:

  • 統合失調症 (SCZD) は,高い遺伝性 (80-85%) とともに,世界全体で1%に罹患しています.
  • 以前の研究では,SCZDにおける脳の体積の減少と神経伝達物質の活性の変化が示されました.
  • SCZDにおける細胞および分子欠陥は,まだ十分に理解されていない.

研究 の 目的:

  • 統合失調症における細胞および分子欠陥を調査する.
  • 患者由来誘発性多能幹細胞 (hiPSCs) を用いてSCZDをモデル化する.

主な方法:

  • SCZD患者の線維芽細胞をhiPSCに直接再プログラムする.
  • SCZD hiPSCsをニューロンに区分する.
  • ニューロンの接続性,遺伝子発現,タンパク質レベルを分析する.
  • SCZDニューロンの治療には,抗精神病薬ロキサピンを使用します.

主要な成果:

  • SCZD hiPSC由来ニューロンは,ニューロン接続性が低下し,ニューライト数が減少し,PSD95およびグルタミン酸受容体発現が低下した.
  • 遺伝子発現プロファイリングは,周期的なAMPとWNTのシグナル伝達経路の変化を明らかにしました.
  • ロッサピン治療は,主要な細胞および分子SCZD現象型を改善しました.

結論:

  • ヒトが誘発した多能幹細胞由来ニューロンは,統合失調症に関連した現象型と遺伝子発現の変化を示す.
  • この研究は,SCZDのような複雑な遺伝的精神疾患を調査するためのモデルを提供します.
  • 発見は,特定されたシグナル伝達経路内の潜在的な治療目標を示唆しています.