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関連する概念動画

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...

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関連する実験動画

Updated: Jun 2, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

長い非コーディングRNAに対するノーンセンスな機能.

Takashi Nagano1, Peter Fraser

  • 1Nuclear Dynamics and Function Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.

Cell
|April 19, 2011
PubMed
まとめ
この要約は機械生成です。

ゲノムの"ダークマター"である長いノンコーディングRNAは,複雑な機能を明らかにしています. 最近の研究では,生物学的プロセスにおけるこれらの謎の分子の多様な役割を明らかにしています.

関連する実験動画

Last Updated: Jun 2, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

科学分野:

  • ゲノミクスゲノミクスとは
  • 分子生物学は分子生物学である.
  • エピジェネティクス エピジェネティクス

背景:

  • 長いノンコーディングRNA (lncRNAs) は,かつては転写ノイズと考えられていた.
  • 遺伝子発現と細胞機能におけるそれらの調節的役割は,ますます認識されています.
  • lncRNAsは,真核生物ゲノムの重要な,まだ十分に研究されていない構成要素を表しています.

研究 の 目的:

  • 長いノンコーディングRNAの複雑で多様な機能を解明する.
  • lncRNAメカニズムの理解における最近の進歩を強調する.
  • ゲノムの"暗黒物質"を探求するために.

主な方法:

  • lncRNA配列と発現データのバイオ情報分析.
  • 機能的ゲノミクス研究,ノックダウンと過剰表現の実験を含む.
  • 新種の lncRNA とその標的を特定するための高通量シーケンシング技術.

主要な成果:

  • 特定の細胞の役割を持つ新しいlncRNAの特定.
  • lncRNAsが遺伝子発現を調節する様々なメカニズムの特徴化.
  • lncRNAsが,発育と病気を含む様々な生物学的経路に関与する証拠.

結論:

  • 長いノンコーディングRNAは,単純な遺伝子調節を超えて,多面的な機能を備えています.
  • これらの分子は,細胞のプロセスと疾患の病原性において重要な役割を果たします.
  • lncRNAsに関するさらなる研究は,ゲノム機能に関する重要な洞察を約束します.