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Updated: Jun 2, 2026

Synthesizing Amino Acids Modified with Reactive Carbonyls in Silico to Assess Structural Effects Using Molecular Dynamics Simulations
05:57

Synthesizing Amino Acids Modified with Reactive Carbonyls in Silico to Assess Structural Effects Using Molecular Dynamics Simulations

Published on: April 26, 2024

タンパク質の酸化ダメージの顕微鏡分析:カルボニレーションがヴィリンヘッドピースの構造,動態,結合能力に及ぼす影響

Drazen Petrov1, Bojan Zagrovic

  • 1Department of Structural and Computational Biology, Max F. Perutz Laboratories, University of Vienna, Campus Vienna Biocenter 5, Vienna AT-1030, Austria.

Journal of the American Chemical Society
|April 22, 2011
PubMed
まとめ

タンパク質の炭基化,酸化的変化は,年齢や病気とともに増加します. 高濃度ではタンパク質の構造が不安定になり,ライシン/アルギニン残基を改変するとタンパク質の集積が強化され,老化に関連する疾患に影響を及ぼします.

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Protein Organization

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