胎児前脳のためのセロトニンの一時的な胎盤の源である
Alexandre Bonnin1, Nick Goeden, Kevin Chen
1Zilkha Neurogenetic Institute, Keck School of Medicine of USC, Los Angeles, California 90089, USA. bonnin@usc.edu
Nature
|April 23, 2011
まとめ
胎盤は,母親のトリプトファンからセロトニン (5-ヒドロキシトリプトミンまたは5-HT) を合成し,胎児の脳の発達と長期的な精神的健康に直接影響を与えます. この胎盤経路は,胚の5-HTの主要な源である.
科学分野:
- 神経科学は神経科学である.
- 発達生物学 発達生物学について
- バイオケミストリー バイオケミストリー
背景:
- セロトニン (5-ヒドロキシトリプタミンまたは5-HT) は神経発達に不可欠です.
- 5-HTを含む母胎の相互作用は,長期的な精神的健康に影響を及ぼします.
- 胎児の神経細胞を超えた胚の5-HTの源は,ほとんど特徴づけられていないままです.
研究 の 目的:
- 胚性5-HT.の中央および周辺の源を調査する.
- 胎盤が胎児の5-HTレベルに寄与するかどうかを判断する.
- 胎児の脳発達における胎盤代謝の役割を明らかにする.
主な方法:
- 5HTニューロンのほとんどの背中のラフェを欠いたペット1 (((-/-) マウスを利用した.
- 先進的なex vivo胎盤生物学技術を採用した.
- 胎盤の5HT新合成を操作し,胎児の脳領域における5HT蓄積を分析した.
主要な成果:
- 胎児の前脳と後脳で5HTの蓄積パターンを特定した.
- 母親の起源から独立した外因的な5-HT源を発見しました.
- マウスとヒトの母親のトリプトファンから5-HTを合成する胎盤経路を発見した.
結論:
- 胎盤は,代謝経路を通じてセロトニン (5-HT) を直接合成する.
- 胎盤の5-HTは胎児の脳の発達を著しく調節する.
- 5-HTを含む母胎胎の相互作用は,長期的な精神的健康の結果にとって重要である.
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