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Updated: Jun 2, 2026

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
10:08

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

Published on: August 28, 2012

人間のIAPPにおけるアミロイド形成メカニズム:ダイマーにはβ鎖のモノマー-モノマーインターフェースがあります

Nicholas F Dupuis1, Chun Wu, Joan-Emma Shea

  • 1Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, USA.

Journal of the American Chemical Society
|April 27, 2011
PubMed
まとめ

人間の小島型アミロイドポリペプチド (hIAPP) の早期オリゴメリゼーションはβ細胞死亡とII型糖尿病 (T2D) を引き起こします. この研究は,ラットのIAPPダイマーとは異なり,hIAPPダイマーがβ鎖に富み,拡張していることを示しています.

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