プロテアゼのパワーストロークは,タンパク質を展開するように強制します
Jorge Alegre-Cebollada1, Pallav Kosuri, Julio M Fernández
1Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Cell
|May 3, 2011
まとめ
ATP依存型プロテアゼは,ATP水解からのエネルギーを利用して,基板を展開し,プロテオリート室に移動させます. この機械的な展開と転位は,単分子光学ピンチを使用して直接実証されます.
科学分野:
- バイオケミストリー バイオケミストリー
- 分子生物学は分子生物学である.
- 細胞生物学 細胞生物学
背景:
- ATP依存型プロテアゼは,細胞溶液中のタンパク質の分解を司る重要な細胞機構である.
- これらのプロテアースが作用する機械的メカニズムを理解することは,細胞タンパク質ホメオスタシスを理解するために不可欠です.
関連する概念動画
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01:13The Proteasome
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02:18The Proteasome
Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
02:18The Proteasome
Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
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Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Structure Is Critical to Its Biological Function
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