関連する実験動画

Updated: Jun 2, 2026

Dissection of Drosophila Ovaries
04:55

Dissection of Drosophila Ovaries

Published on: October 19, 2006

保存されたFボックス調節複合体は,ドロソフィラのプロテアゾーム活動を制御する

Maya Bader1, Sigi Benjamin, Orly L Wapinski

  • 1Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA.

Cell
|May 3, 2011
PubMed
まとめ

最近発見されたタンパク質DmPI31は,プロテアソーム機能を調節し,ドロソフィラの精子の分化に不可欠である. この発見は,タンパク質の分解と細胞サイクル進行を制御する保存されたメカニズムを強調しています.

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Assaying Proteasomal Degradation in a Cell-free System in Plants07:43

Assaying Proteasomal Degradation in a Cell-free System in Plants

Published on: March 26, 2014

Medium-scale Preparation of Drosophila Embryo Extracts for Proteomic Experiments09:16

Medium-scale Preparation of Drosophila Embryo Extracts for Proteomic Experiments

Published on: May 30, 2017

関連する概念動画

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Protein Complexes with Interchangeable Parts

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Conservation of Protein Domains Over Different Proteins

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Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
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Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...
The Proteasome02:18

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...