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マクロ分子混雑は,細胞内の球状タンパク質を折りたたむのに失敗する

Alexander P Schlesinger1, Yaqiang Wang, Xavier Tadeo

  • 1Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Journal of the American Chemical Society
|May 4, 2011
PubMed
まとめ

細胞の混雑は,排除された体積を通じてタンパク質を安定させるが,非特異的な相互作用は,この効果を相殺することができる. 研究によると,E. coliの細胞質はタンパク質の変種を完全に安定させないため,これらの相互作用が有意であることを示唆しています.

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