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アミノアダマンタンはどのようにインフルエンザM2チャネルを遮断し,どのようにして耐性が生じるのでしょうか?

Hadas Leonov1, Peleg Astrahan, Miriam Krugliak

  • 1Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmund J. Safra Campus, Jerusalem 91904, Israel.

Journal of the American Chemical Society
|May 4, 2011
PubMed
まとめ

アミノアダマンチルは,静電阻害によってインフルエンザM2チャネルを遮断する. 変異は結合ポケットを拡大して耐性を引き起こし,薬の移動性を可能にし,阻害を防止し,新しい抗ウイルス設計を支援します.

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