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Updated: Jun 2, 2026

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
07:56

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron

Published on: August 12, 2019

アミノチオカルバマート触媒を用いたエナンチオセレクティブブロモアミノサイクリング

Ling Zhou1, Jie Chen, Chong Kiat Tan

  • 1Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.

Journal of the American Chemical Society
|May 5, 2011
PubMed
まとめ

新しい触媒的方法により,不飽和のスルフォナミドからピロリジンのエナチオセレクティブ合成が可能になりました. この効率的なプロセスは,乳糖合成の貴重な前駆体である高度にエナンチオ濃縮されたピロリジンを生成します.

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Amines to Amides: Acylation of Amines

Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary amide...
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Preparation of Amines: Reductive Amination of Aldehydes and Ketones

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α-Bromination of Carboxylic Acids: Hell–Volhard–Zelinski Reaction

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Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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