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Updated: Jun 2, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

薬の分子はどのように標的の結合部位を見つけますか?

Yibing Shan1, Eric T Kim, Michael P Eastwood

  • 1D. E. Shaw Research, New York, New York 10036, USA.

Journal of the American Chemical Society
|May 7, 2011
PubMed
まとめ

分子ダイナミクスシミュレーションでは,ダサチニブのような薬剤分子がタンパク質ターゲットに結合し,原子レベルのプロセスを明らかにした. この方法は,新薬の結合部位,特にアロステル抑制剤の結合部位を発見するのに役立ちます.

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