ヒトパピローマウイルス型および再発性子宮頸
1Department of Pathology, Columbia Presbyterian Medical Center, New York, NY.
JAMA
|March 2, 1990
まとめ
低温治療後の子宮頸部内皮質内腫瘍 (CIN) の再発は,通常,元の病変とは異なるヒトパピローマウイルス (HPV) タイプによって引き起こされます. しかし,同時に発生するCINは,しばしば同じHPV型を共有する.
科学分野:
- 婦人科 婦人科について
- 腫瘍学 腫瘍学
- ウイルス学 ウイルス学 ウイルス学
背景:
- 子宮頸内膜内腫瘍症 (CIN) は,子宮頸部の癌前状態である.
- ヒトパピローマウイルス (HPV) は,CIN.の主要な原因です.
- 低温治療はCINの一般的な治療法ですが,再発は起こりえます.
研究 の 目的:
- 低温治療後の再発性CINが,元の病変と同じHPV型と関連しているかどうかを調査する.
- 再発性CINにおけるHPV型と,同時に発生するCIN病変におけるHPV型を比較する.
主な方法:
- 子宮頸部組織サンプルにおけるHPVDNAの分析.
- 低温治療前のCIN病変におけるHPVタイプの比較と冷凍治療後の比較.
- 同時に発生するCIN病変におけるHPVタイプの比較.
主要な成果:
- 低温治療後に再発したCINを患った8人の女性は,治療前の病変と比較して,治療後の病変で異なるHPV型を示しました.
- 同時期にCINを発症した12人の女性では,病変全体 (11例中12例) に共通するHPV型が優勢であった.
結論:
- 低温治療後の再発性CINは,新しいHPV感染または異なるHPV型と頻繁に関連しています.
- 同時に発生するCINの病変は,同じHPV型によって引き起こされる可能性が高くなります.
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