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Updated: Jun 1, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

固体相合成,熱性デナチュレーション研究,ヌクレアゼ耐性,および (オリゴデオキシリボヌクレオシド) メチルボランフォスフィン-DNAキメラの細胞吸収

Heera Krishna1, Marvin H Caruthers

  • 1Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado 80309, USA.

Journal of the American Chemical Society
|May 19, 2011
PubMed
まとめ

新しいメチルボラン・フォスフィン (Me-P-BH(3)) オリゴデオキシヌクレオチド (ODN) は,高耐核酸と効率的な細胞吸収を示しています. これらの改変されたODNは,反感覚研究とRNA干渉 (RNAi) アプリケーションに有望である.

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