関連する実験動画

Updated: Jan 24, 2026

Coordinate Mapping of Hyolaryngeal Mechanics in Swallowing
14:13

Coordinate Mapping of Hyolaryngeal Mechanics in Swallowing

Published on: May 6, 2014

18.7K

pK(a) インテインの活性部位での結合:保存されたアスパルテートとタンパク質のスプライシングの調整機構への影響

Zhenming Du1, Yuchuan Zheng, Melissa Patterson

  • 1Biology Department, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.

Journal of the American Chemical Society
|May 25, 2011
PubMed
まとめ

この研究では,Mutu RecAインテインの特定のアスパルテート残留物が,タンパク質のスプライシングを促進するために,そのユニークな高いpKaを使用する方法が明らかにされています. このアスパルテートの連続したプロトン化とデプロトン化が,この重要な翻訳後の改変の初期段階を調整する.

さらに関連する動画

Synthesis of an Intein-mediated Artificial Protein Hydrogel15:06

Synthesis of an Intein-mediated Artificial Protein Hydrogel

Published on: January 27, 2014

12.7K
Quantifying Agonist Activity at G Protein-coupled Receptors11:45

Quantifying Agonist Activity at G Protein-coupled Receptors

Published on: December 26, 2011

19.8K

関連する概念動画

Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.1K
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
24.8K
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
4.1K
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.5K
Conservation of Mechanical Energy01:05

Conservation of Mechanical Energy

The mechanical energy E of a system is the sum of its potential energy U and the kinetic energy K of the objects within it. What happens to this mechanical energy when only conservative forces cause energy transfers within the system—that is, when frictional and drag forces do not act on the objects in the system? Also assume that the system is isolated from its environment; in other words no external force from an object outside the system causes energy changes inside the system.
When a...
24.9K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
131.7K