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Updated: Jun 1, 2026

Analysis of SAMHD1 Restriction by Flow Cytometry in Human Myeloid U937 Cells
09:43

Analysis of SAMHD1 Restriction by Flow Cytometry in Human Myeloid U937 Cells

Published on: June 13, 2021

SAMHD1は,Vpxpxによって相殺される,デンドリット細胞およびミエロイド細胞特異的なHIV-1制限因子です

Nadine Laguette1, Bijan Sobhian, Nicoletta Casartelli

  • 1Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000, France. nadine.laguette@igh.cnrs.fr

Nature
|May 27, 2011
PubMed
まとめ

霊長類のレンチウイルスタンパク質Vpxは,骨髄性細胞におけるHIV-1感染を制限する制限因子であるSAMHD1を分解する. この発見は,SAMHD1をHIV-1治療の重要な抗レトロウイルス標的として明らかにしています.

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Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.08:11

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