脊椎動物の肢体における近接-遠隔のパターンの開始は,信号と成長によって行われます
Kimberly L Cooper1, Jimmy Kuang-Hsien Hu, Derk ten Berge
1Harvard Medical School, Department of Genetics, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Science (New York, N.Y.)
|May 28, 2011
まとめ
幼鳥の早期の足の発達は,メゼンキームがすべてのセグメントを形成できることを明らかにします. プロキシマルパターニングは側面の信号に依存し,中間と遠端のセグメントは,この影響を超えて発達する.
科学分野:
- 発達生物学 発達生物学について
- 肢体形態発生 肢体形態発生
- 脊椎動物の胚学について
背景:
- 脊椎動物の四肢の近辺-遠辺軸は,四肢形成に極めて重要です.
- 既存のモデルは,四肢のパターニングの異なるメカニズムを提案しています.
- 肢体セグメントの発達を理解することは,発達生物学の鍵です.
研究 の 目的:
- 手足近辺-遠辺軸のパターニングの提案されたモデルを区別する.
- すべての四肢のセグメントを生成する初期の四肢メゼンキムの役割を調査する.
- 肢体セグメントの発達を支えるシグナル伝達メカニズムを解明する.
主な方法:
- 組み合わせた in vitroとin vivoの培養システムを利用しました.
- チークの四肢メゼンキームの発達を分析した.
- 手足のパターニングに近辺と遠端のシグナル伝達の影響を調査した.
主要な成果:
- 初期のチキの四肢メゼンキームは,最初はプラスチックで,すべてのセグメントを形成することができます.
- 隣接四肢のパターンは,連続した側面派生シグナルによって維持されます.
- 端末中央部および端末端部セグメントの発達は,近接信号の影響を超えて成長する領域で開始されます.
結論:
- この研究は,四肢メゼンキームが最初は均等であるモデルを支持する証拠を提供します.
- 肢体のパターニングは,近接信号依存から内在的な発達プログラムへの移行を伴う.
- 開発された培養システムは,四肢のパターニングメカニズムを研究するための新しい道を開く.
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