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Updated: Jun 1, 2026

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)
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DNAのマイナー・グリューブをターゲットとする剤の水媒介結合

Yang Liu1, Arvind Kumar, Sabine Depauw

  • 1Department of Chemistry, Georgia State University, Atlanta, Georgia 30302-4098, USA.

Journal of the American Chemical Society
|June 2, 2011
PubMed
まとめ

この研究では,水分子がDNAへの小さな分子結合を媒介する方法を調査し,DNAを標的とする薬剤設計に関する新しい洞察を明らかにしています. DB921化合物の改変は,治療応用のための新しいアプローチを提供します.

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