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関連する概念動画

Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
Nucleic acids02:43

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...

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関連する実験動画

Updated: Jun 1, 2026

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
10:58

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

多価核酸ナノ構造である多価核酸ナノ構造は,

Joshua I Cutler1, Ke Zhang, Dan Zheng

  • 1Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.

Journal of the American Chemical Society
|June 3, 2011
PubMed
まとめ
この要約は機械生成です。

研究者らは,改良された遺伝子調節のための新しい多価核酸ナノ構造 (PNANs) を開発した. これらの自己組み立て核酸粒子は,キャリアを必要とせずに,高い細胞吸収率と核酵素抵抗性を示す.

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Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
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Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods

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A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
08:07

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

関連する実験動画

Last Updated: Jun 1, 2026

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
10:58

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
09:12

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods

Published on: May 11, 2018

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
08:07

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

科学分野:

  • バイオテクノロジー バイオテクノロジー
  • ナノテクノロジー ナノテクノロジー
  • 分子生物学は分子生物学である.

背景:

  • 多価オリゴヌクレオチド・ナノ粒子結合体は,細胞の吸収,生物活性,およびヌクレアゼ抵抗性を高めています.
  • これらの性質は,オリゴヌクレオチドがナノ粒子表面に密集して配置されていることによるものです.

研究 の 目的:

  • 多価核酸ナノ構造 (PNANs) の新種を導入し,交互にリンクされた,指向された核酸からのみ構成する.
  • 細胞の吸収と遺伝子調節におけるPNANの有効性を証明するために,カチオンのポリマーの共同キャリアなしで.

主な方法:

  • 相互リンクおよび指向された核酸ナノ構造 (PNANs) の合成.
  • 細胞吸収効率の評価. 細胞吸収効率の評価. 細胞吸収効率の評価. 細胞吸収効率の評価. 細胞吸収効率の評価.
  • 遺伝子調節能力の評価 遺伝子調節能力の評価
  • 結合行動とヌクレアゼ抵抗性の分析.

主要な成果:

  • PNANは高細胞吸収と遺伝子調節をキャチオンポリマー共同キャリアなしで達成する.
  • ナノ構造は協力的な結合行動を示す.
  • PNANは,核酵素への有意な耐性を示しています.

結論:

  • PNANは,自己組み立ての核酸ナノ構造の新しいクラスを表しています.
  • これらの構造は,強化された遺伝子調節とオリゴヌクレオチド配送のためのキャリアフリーアプローチを提供します.
  • PNANは,安定性と生物学的活性を改善するための固有の特性を有しています.