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引用数が多い個々の記事と,その後のメタ解析で報告されたバイオマーカーに関連した効果の大きさの比較

John P A Ioannidis1, Orestis A Panagiotou

  • 1Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA. jioannid@stanford.edu

JAMA
|June 3, 2011
PubMed
まとめ

よく引用されているバイオマーカー研究は,後のメタ解析と比較して,しばしば効果の大きさを過大評価しています. これは,疾患リスクと予後バイオマーカーの早期発見における潜在的インフレを示唆しています.

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