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関連する概念動画

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship01:29

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic antagonists are called...
Stereoisomers02:32

Stereoisomers

On the basis of mirror symmetry, stereoisomers of an organic molecule can be further classified into diastereomers and enantiomers. Diastereomers are stereoisomers that are not mirror images of each other. Substituted alkenes, such as the cis and trans isomers of 2-butene, are diastereomers, as these molecules exhibit different spatial orientations of their constituent atoms, are not mirror images of each other, and do not interconvert. Here, the interconversion is suppressed due to restricted...
Adrenergic Agonists: Chemistry and Structure-Activity Relationship01:16

Adrenergic Agonists: Chemistry and Structure-Activity Relationship

Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...
Stereoisomerism02:52

Stereoisomerism

Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Prochirality02:05

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons00:58

¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons

Replacing each alpha-hydrogen in chloroethane by bromine (or a different functional group) yields a pair of enantiomers. Such protons are called prochiral or enantiotopic and are related by a mirror plane. Enantiotopic protons are chemically equivalent in an achiral environment. Because most proton NMR spectra are recorded using achiral solvents, enantiotopic hydrogens yield a single signal.
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...

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Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
11:44

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids

Published on: February 21, 2018

ペプトイドアトロピソマーであるペプトイドアトロピソマー

Bishwajit Paul1, Glenn L Butterfoss, Mikki G Boswell

  • 1Department of Chemistry, New York University, New York, New York 10003, USA.

Journal of the American Chemical Society
|June 4, 2011
PubMed
まとめ
この要約は機械生成です。

研究者らは,軸性キラリティを持つN-アリルペプトイドオリゴーマーを開発し,安定した分離可能な形態を可能にしました. この画期的な発見は,折りたたみの形状と構造を制御するための新しい方法を提供します.

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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
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Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
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Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

関連する実験動画

Last Updated: Jun 1, 2026

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
11:44

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids

Published on: February 21, 2018

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
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Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

科学分野:

  • 有機化学 オーガニック・ケミストリー
  • ポリマーサイエンスの科学
  • 化学結晶学 化学結晶学とは

背景:

  • フォルダマーとは,タンパク質の二次構造を模倣する合成ポリマーである.
  • 折り畳み材料の構造安定性とキラリティを制御することは,その用途にとって極めて重要です.
  • N-アリルペプトイドは,多様な構造モチーフを持つ可能性のある折り畳み物の一種です.

研究 の 目的:

  • 軸性キラリティを示すN-アリルペプトイドオリゴーマーを分離し,特徴づけること.
  • ステレオジェニックな炭素-窒素結合の周りの回転エネルギーバリアを調査する.
  • 折りたたみの化合物における構成順序を誘導するための新しい戦略を探求する.

主な方法:

  • オルソ置換されたN-アリル側鎖によるN-アリルペプトイド単体合成.
  • アトロピゾメリズムを研究するための計算モデリング.
  • 核磁共振 (NMR) スペクトロスコーピー. 核磁共振 (NMR) スペクトロスコーピー. 核磁共振 (NMR) スペクトロスコーピー.
  • X線結晶学.X線結晶学.X線結晶学.
  • アトロピソメアの分離のための高性能液体染色法 (HPLC).
  • 円形の二重化 (CD) スペクトロスコーピー.

主要な成果:

  • 伝統的なキラルセンターなしでキラル折り合いを採用するN-アリルペプトイドオリゴマーの分離.
  • C-N結合の周りの回転が制限されているため,軸性キラリティを示すモノマーの識別.
  • 安定したアトロピソメア形態の浄化を可能にする,回転に対する重要なエネルギーバリアの実証.
  • 計算技術と実験技術の組み合わせを用いた詳細な構造と構成分析.

結論:

  • N-アリルペプトイドオリゴマーは軸性キラリティを達成し,安定した分離可能なアトロピゾーマーにつながる.
  • この発見は,折り畳み材料の形状特性を制御するための新しい方法を提供します.
  • この発見は,新しい折りたたみ基の材料と触媒を設計するための道を開く.