Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Forecasting left ventricular systolic dysfunction in heart failure with artificial intelligence.

EClinicalMedicine·2026
Same author

Artificial intelligence for hemodynamic monitoring with a wearable electrocardiogram monitor.

Communications medicine·2025
Same author

What is AI and why should I care?

Heart rhythm·2024
Same author

Increasing acceptance of AI-generated digital twins through clinical trial applications.

Clinical and translational science·2024
Same author

A Deep Learning Model for Inferring Elevated Pulmonary Capillary Wedge Pressures From the 12-Lead Electrocardiogram.

JACC. Advances·2024
Same author

Machine Learning for Risk Prediction: Does One Size Really Fit All?

JACC. Advances·2024

関連する実験動画

Updated: Jun 1, 2026

NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins
09:25

NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins

Published on: November 1, 2024

秩序-乱雑連続体に沿ったタンパク質構造.

Charles K Fisher1, Collin M Stultz

  • 1Committee on Higher Degrees in Biophysics, Harvard University, Cambridge, Massachusetts 02139-4307, USA.

Journal of the American Chemical Society
|June 10, 2011
PubMed
まとめ

この研究では,タンパク質の構成的異質性を定量化するための新しい情報理論的順序パラメータを導入しています. このメトリックは,折りたたまれた状態から開いた状態までのタンパク質構造の範囲を効果的に測定します.

科学分野:

  • バイオフィジックス 生物物理学
  • 構造生物学 構造生物学とは
  • コンピュータ生物学 コンピュータ生物学

背景:

  • タンパク質は,そのエネルギー環境によって影響される形状の集合体として存在します.
  • 既存の"折りたたみ"と"開き"の分類は,構造的異質性の質的見解を提供します.
  • 形状的異質性を定量化することは,タンパク質の動態を理解するために重要である.

研究 の 目的:

  • タンパク質の形状的異質性を定量化するための新しい情報理論的順序パラメータを導入する.
  • 折りたたまれたタンパク質と開いたタンパク質の両方にパラメータの適用性を示すために.
  • このパラメータを結晶学B因子から近似する方法を提供する.

主な方法:

  • 情報理論的順序パラメータの開発.
  • タンパク質構成集合から順序パラメータの推定.
  • 結晶学的B因子を用いて順序パラメータを近似するための式を導出する.

主要な成果:

  • 提案された順序パラメータは,さまざまなタンパク質状態における構成異質性を成功裏に定量化しています.
  • 順序パラメータは,構成集合から容易に推定できます.

さらに関連する動画

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

関連する実験動画

Last Updated: Jun 1, 2026

NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins
09:25

NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins

Published on: November 1, 2024

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

  • B-ファクターを用いた簡単な近似は実行可能である.
  • 大量のタンパク質データセットの分析は,秩序-乱雑の完全なスペクトルを明らかにします.

    • 結論:

    • 開発された順序パラメータは,タンパク質の構造的異質性を定量的に測定します.
    • このメトリックは,タンパク質状態の質的分類と定量的記述の間のギャップを埋めます.
    • タンパク質は連続した形状の柔軟性を発揮し,折りたたまれた/開いた二進制の区別に挑戦します.