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Updated: Jun 1, 2026

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
10:56

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

Published on: May 17, 2014

フォスフォプロテオミック分析により,Grb10はmTORC1の基板であり,インスリンシグナル伝達を否定的に調節するものであることが判明した

Yonghao Yu1, Sang-Oh Yoon, George Poulogiannis

  • 1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|June 11, 2011
PubMed
まとめ

ラパミシン (mTOR) 経路の哺乳類の標的は,細胞プロセスを調節する. 新しい研究は,成長因子受容体結合タンパク質10 (Grb10) をmTORC1基質として特定し,癌におけるその役割を明らかにしています.

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