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Updated: Jun 1, 2026

Assessment of DNase Activity by Ratiometric Fluorescence Resonance Energy Transfer
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RB69 DNAポリメラーゼ三重複合体のテンプレート型ディフルオロトルーエンヌクレオチド残基の水素結合能力

Shuangluo Xia1, William H Konigsberg, Jimin Wang

  • 1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.

Journal of the American Chemical Society
|June 15, 2011
PubMed
まとめ

この研究では,非極性チミンイソステルである2,4-二酸化流体オルエンの核塩基 (dF) が,DNA複製中に新しい水素結合を形成できることを明らかにしました. これは,DNAポリメラーゼが伝統的な塩基配列なしでDNAを正確に複製できることを示すことで,ワトソン・クリックの教義に挑戦しています.

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