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Updated: May 1, 2026

Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects
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Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects

Published on: February 17, 2016

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マウスの遺伝子機能の全ゲノム研究のための条件付きノックアウトリソース.

William C Skarnes1, Barry Rosen, Anthony P West

  • 1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. skarnes@sanger.ac.uk

Nature
|June 17, 2011
PubMed
まとめ

研究者らは,マウスの胚性幹細胞で,リポータータグ付きの条件性遺伝子アレルを作成するための高通量パイプラインを開発した. このスケーラブルな方法は,哺乳類の遺伝子機能を理解するための標的型変異の生成を加速します.

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Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

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Tracing Gene Expression Through Detection of β-galactosidase Activity in Whole Mouse Embryos

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関連する概念動画

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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