病原体レジオネラ肺炎菌による小さなGTPase Rab1のデアンピレーション

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Updated: May 31, 2026

Purification of Pathogen Vacuoles from Legionella-infected Phagocytes
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Purification of Pathogen Vacuoles from Legionella-infected Phagocytes

Published on: June 19, 2012

M Ramona Neunuebel1, Yang Chen, Andrew H Gaspar

  • 1Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|June 18, 2011
PubMed
まとめ

レジオネラ肺炎菌は,エフェクタ SidD を使用して,宿主タンパク質 Rab1.1 から AMP を除去します. このde-AMPylationにより,LepBはRab1を無効化し,宿主細胞から病原体のクリアランスを促進します.

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