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SIRT6は,PARP1を活性化することによって,ストレス下でのDNA修復を促進します

Zhiyong Mao1, Christopher Hine, Xiao Tian

  • 1Department of Biology, University of Rochester, Rochester, NY 14627, USA.

Science (New York, N.Y.)
|June 18, 2011
PubMed
まとめ

Sirtuin 6 (SIRT6) タンパク質は,酸化ストレス中にDNAの二重鎖断裂 (DSB) を修復する. これは,ポリアドプリボゼ) ポリメラーゼ1 (PARP1) の活性を変更することによって,修復を促進します.

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