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Updated: May 31, 2026

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
09:27

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains

Published on: January 5, 2016

ゴッシャー病のグルコセレブロシダゼとα-シヌクレインは,シヌクレイン病変において双方向の病原性ループを形成する

Joseph R Mazzulli1, You-Hai Xu, Ying Sun

  • 1Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA.

Cell
|June 25, 2011
PubMed
まとめ

パーキンソン病は,グルコセレブロシダゼ (GCase) によるゴーシャー病と関連している. GCaseの機能の喪失はタンパク質の分解を阻害し,アルファ-シヌクレインの蓄積と神経毒性を引き起こし,共通の疾患メカニズムを示唆します.

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A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model08:24

A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model

Published on: November 25, 2022

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons10:03

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons

Published on: August 16, 2020

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