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Updated: May 31, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

Published on: June 20, 2014

初期C−H結合の活性化を経由して,イリジウムへのC−sp3−F結合の純酸化添加

Jongwook Choi1, David Y Wang, Sabuj Kundu

  • 1Department of Chemistry and Chemical Biology, Rutgers, State University of New Jersey, New Brunswick, NJ 08903, USA.

Science (New York, N.Y.)
|June 25, 2011
PubMed
まとめ

研究者は,アリファティック化合物の強い炭素-フッ素結合を断ち切る新しい方法を開発しました. このブレークスルーは,炭素-水素結合を活性化して,困難な炭素-フッ素結合を分裂させ,新しい触媒戦略を提供することを含む.

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Radical reactions can occur either intermolecularly or intramolecularly. In an intermolecular radical reaction, a nucleophilic radical adds to an electrophilic alkene or vice versa. In such reactions, the radical and generally the alkene, which is also called the radical trap, are two different molecules. Additionally, for such intermolecular reactions to occur, the radical trap must be active, present in an excess concentration, and the radical starting material must have a weak carbon–halogen...