術後の急性痛の治療について
Christopher L Wu1, Srinivasa N Raja
1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University and School of Medicine, Baltimore, MD 21287, USA. chwu@jhmi.edu
Lancet (London, England)
|June 28, 2011
まとめ
痛みのメカニズムの理解が向上したことで,術後の痛みのコントロールが進歩しました. 地域性鎮痛薬や新薬を含む新しい治療法は,急性疼痛管理のより良い患者の結果を提供します.
科学分野:
- 痛みの研究と麻酔学.
- 薬理学と分子生物学.
- 外科患者のケア.
背景:
- 術後の痛み管理は改善されていますが,課題は残っています.
- ノシセプションのメカニズムはますます理解されています.
- オピオイドに起因する過敏症と持続的な痛みは大きな懸念事項です.
研究 の 目的:
- 痛みのメカニズムの理解における進歩をレビューする.
- 急性手術後の痛みに対する新しい治療アプローチを探求する.
- 地域鎮痛剤と新薬剤の役割について議論する.
主な方法:
- 痛みの研究における最近の進歩に関する文献レビュー.
- 新興の鎮痛技術と薬物の分析.
- 急性手術後の痛みに対する治療方法の検討.
主要な成果:
- nociceptionの理解は,遺伝子ベースの治療の研究を刺激しました.
- 地域性鎮痛薬は,患者の治療結果を改善する見通しを示しています.
- 新しい鎮痛剤と治療法の開発が進行中です.
結論:
- 疼痛科学の進歩は,手術後の痛みの管理のための新しい道を開く.
- 地域技術や新薬を含むマルチモダルのアプローチが鍵となる.
- 継続的な研究は,急性痛のコントロールと患者の回復を最適化するために不可欠です.
関連する概念動画
Peripheral Artery Disease V: Postoperative Nursing Management
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Analgesia and Pain Management
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
Aneurysm IV: Nursing Management
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
Tonsillitis II: Management
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
