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Updated: May 31, 2026

A Fluorescence-Based Assay of Membrane Potential for High-Throughput Functional Study of Two Endogenous Ion Channels in Two Epithelial Cell Lines
06:59

A Fluorescence-Based Assay of Membrane Potential for High-Throughput Functional Study of Two Endogenous Ion Channels in Two Epithelial Cell Lines

Published on: June 22, 2022

陽子チャンネルM2の2つの薬物結合部位における自由エネルギーの計算

Ruo-Xu Gu1, Limin Angela Liu, Dong-Qing Wei

  • 1State Key Laboratory of Microbial Metabolism, Luc Montagnier Biomedical Research Institute, and College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai Minhang District, China 200240.

Journal of the American Chemical Society
|June 30, 2011
PubMed
まとめ

インフルエンザAのM2チャネルを標的にするアダマンタン型薬は,毛穴の内部により安定的に結合しますが,より高いエネルギーが必要です. C末端の表面は,これらの抗ウイルス薬のための運動的に有利な結合部位を提供します.

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