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Updated: May 31, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Published on: December 10, 2021

Lgr5の同類体はWnt受容体と結合し,R-スポンジンのシグナル伝達を媒介する

Wim de Lau1, Nick Barker, Teck Y Low

  • 1Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.

Nature
|July 6, 2011
PubMed
まとめ

レウシンに富んだGタンパク質結合受容体5 (Lgr5) とLgr4は,Wnt経路の重要な構成要素である. これらの遺伝子を削除すると腸の幹細胞機能が低下しますが,R-スポンジンはLgr4/5.5経由でWnt信号伝達を強化することができます.

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