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Updated: May 31, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
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Published on: April 26, 2013

G-DNAの構造的ポリモルフィズムと配列とループの接続性からの折り畳み,自由エネルギー分析による洞察

Xiaohui Cang1, Jiří Šponer, Thomas E Cheatham

  • 1Department of Medicinal Chemistry, College of Pharmacy, Skaggs Hall 201, University of Utah, Salt Lake City, Utah 84112, USA.

Journal of the American Chemical Society
|July 19, 2011
PubMed
まとめ

G-quadruplexの折りたたみと安定性は,ループとG-tractの長さに依存しています. 分子ダイナミクスのシミュレーションにより,ループの長さとシーケンスがG四重複構造に大きく影響し,その安定性と形成に関する新しい洞察を提供していることが明らかになりました.

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