関連する実験動画

Updated: May 30, 2026

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions
06:55

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions

Published on: June 7, 2020

タンパク質の折りたたみとプロテオスタシスにおける分子チャペロン

F Ulrich Hartl1, Andreas Bracher, Manajit Hayer-Hartl

  • 1Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany. uhartl@biochem.mpg.de

Nature
|July 22, 2011
PubMed
まとめ

細胞は分子チャペロンを用いて,適切なタンパク質の折り畳みを確保し,毒性の蓄積を防止し,タンパク質ホメオスタシス (プロテオスタシス) を維持します. 年齢とともにタンパク質静止が低下することは,アルツハイマー病やパーキンソン病などの神経退行性疾患と関連しています.

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