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Updated: May 30, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

超膜ヘリクスを標的とするβペプチドの計算設計

Scott J Shandler1, Ivan V Korendovych, David T Moore

  • 1Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

Journal of the American Chemical Society
|July 26, 2011
PubMed
まとめ

膜タンパク質の標的のためのβ-ペプチド折り合いを設計することは困難です. 研究者らは,インテグリン α(IIb) β(3) を標的とし,そのトランスメブラン領域と相互作用することによって活性化するβ-ペプチド (β-CHAMP) を作成した.

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