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Updated: May 30, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
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MAVSは,抗ウイルス性先天性免疫応答を活性化し,拡散させるための機能的なプリオンのような集合体を形成します

Fajian Hou1, Lijun Sun, Hui Zheng

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

Cell
|July 26, 2011
PubMed
まとめ

ウイルス感染症は,RIG-Iのようなヘリケアスを誘発して,MAVSの集積を活性化させ,抗ウイルス信号を伝播するプリオンのような構造を形成します. このメカニズムは,MAVSアグレガートがIRF3を活性化し,免疫反応を強める方法を説明します.

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