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Updated: May 30, 2026

Two-Step Tag-Free Isolation of Mitochondria for Improved Protein Discovery and Quantification
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ミトコンドリア解離タンパク質2構造は,NMR分子断片探査により決定される

Marcelo J Berardi1, William M Shih, Stephen C Harrison

  • 1Jack and Eileen Connors Structural Biology Laboratory, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|July 26, 2011
PubMed
まとめ

ミトコンドリア解離タンパク質2 (UCP2) の構造は,新しい溶液-NMR法を使用して決定されました. これは,UCP2を明らかにします.

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Mitochondrial Precursor Proteins

Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70  chaperones are targetted to TOM20-TOM22 receptor complexes.
Most of the mitochondrial precursors...
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