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Updated: May 3, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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非ホジキンリンパ腫におけるヒストン修飾遺伝子の頻繁な変異

Ryan D Morin1, Maria Mendez-Lago, Andrew J Mungall

  • 1Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.

Nature
|July 29, 2011
PubMed
まとめ

この研究では,非ホジキンリンパ腫 (NHL) の変異遺伝子を109個特定し,MLL2およびMEF2Bなどのヒストンの改変に関与する遺伝子の頻繁に発生する変異を明らかにし,小胞性リンパ腫 (FL) および拡散性大B細胞リンパ腫 (DLBCL) に関する変異を明らかにしました. これらの発見は,リンパマゲネシスにおけるクロマチンの生物学的破壊を強調しています.

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