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ceRNA仮説:隠されたRNA言語のロゼッタ・ストーン?
Leonardo Salmena1, Laura Poliseno, Yvonne Tay
1Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Cell
|August 2, 2011
まとめ
メッセンジャーRNA,偽遺伝子,および長いノンコーディングRNAは,競合する内生RNA (ceRNA) ネットワークを形成する. このトランスクリプトーム全体の規制ネットワークは,マイクロRNA応答要素 (MREs) を使用し,癌などの病気に影響を与えます.
科学分野:
- 分子生物学は分子生物学である.
- ゲノミクスゲノミクスとは
- RNA 生物学 RNA 生物学
背景:
- 人間のゲノムには,タンパク質をコードするメッセンジャーRNA (mRNA) を超える多様なRNA分子が含まれています.
- 長い非コーディングRNA (lncRNAs) と転写された偽遺伝子は,大部分が未知の機能を持つトランスクリプトームの重要な部分を表しています.
- マイクロRNA (miRNA) は遺伝子発現の重要な調節体であり,主にmiRNA応答要素 (MREs) に結合する.
研究 の 目的:
- mRNA,lncRNA,および偽遺伝子の間の規制相互作用に関する統一的仮説を提案する.
- 新規の規制メカニズムとして,競合する内生RNA (ceRNA) 活動という概念を導入する.
- 人間の病気,特に癌における ceRNA ネットワークの潜在的な役割を強調する.
主な方法:
- この研究は,主に仮説主導の理論的枠組みである.
- RNA-RNAの相互作用とmiRNAの調節に関する既存の知識を統合しています.
- RNA通信の共有言語としてのMREsの概念は,この仮説の中心にある.
主要な成果:
- メッセンジャーRNA,転写された偽遺伝子,および長いノンコーディングRNAは,共有されたMREsを通じて相互作用することができます.
- この相互作用は,トランスクリプトーム全体に広がる大規模な競合する内生RNA (ceRNA) 規制ネットワークを形成する.
- ceRNAの活動は,ヒトゲノム内にコードされている機能的な遺伝情報を大幅に拡張します.
結論:
- ceRNA仮説は,転写後の調節を理解するための新しい枠組みを提供します.
- ceRNAネットワークは,細胞機能に重大な影響を及ぼす広範な規制層を表しています.
- ceRNAネットワークの調節不良は,がんを含む様々な疾患の病原化に関与しており,潜在的な治療標的を提供している.
関連する概念動画
Types of RNA
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
RNA Interference
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
RNA Stability
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
RNA Stability
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
RNA Interference
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Types of RNA
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...

