身体活動と冠動脈疾患のリスクとの間の用量反応:メタ解析
Jacob Sattelmair1, Jeremy Pertman, Eric L Ding
1Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. sattelmair@post.harvard.edu
Circulation
|August 4, 2011
まとめ
定期的な身体活動に従事すると,冠動脈疾患のリスクが著しく低下します. 推奨ガイドラインを下回った金額でも,より多くの活動が,特に女性にとって,追加の保護を提供することで,利点を提供します.
科学分野:
- 心血管の健康について
- 予防医学は,予防的な医療です.
- エピデミオロジー エピデミオロジー
背景:
- 以前のレビューでは,冠動脈性心疾患 (CHD) のリスク低下に対する身体活動量-反応に関する定量的なデータが欠けていました.
- 以前は,定性的な見積もり (低,中,高) が使用され,正確なガイドラインの開発を妨げていました.
研究 の 目的:
- 身体活動と冠動脈性心疾患の初次予防の間の用量反応関係を定量化するために.
- 既存の身体活動ガイドラインを支える証拠に基づいたデータを提供すること.
主な方法:
- 1995年以来発表された前向きコホート研究の集約データメタ解析.
- 3194の要約をスクリーニングした後の33件の研究の含有.
- ランダム効果を活用し,トレンドの見積もりをするために一般化された最小二乗のスプラインモデルを使用した.
主要な成果:
- 週150分程度の中等強度の運動は,14%低い心血管疾患リスクと関連していました.
- 週300分程度の中等強度の運動は,心血管疾患のリスクが20%低いことを示しました.
- 推奨される最低限の活動レベルを下回ったレベルでも,女性ではより強い関連性があり,有意な利益が観察されました.
結論:
- 定量的な証拠は,あらゆる身体活動が,心血管疾患のリスクを減らすのに有益であることを支持しています.
- 増加した身体活動レベルは,現在の米国のガイドラインに沿って,追加の利益をもたらします.
- 研究結果は,心臓血管の健康,特に女性にとって,身体活動の重要性を強調しています.
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